In summary, NNMT induces EGFR expression by reducing the levels of H3K9me3 and H3K27me3 in the EGFR promoter region, thereby activating the EGFR-STAT3 signaling pathway to promote the intracellular glycolysis process, proliferation, and metastasis in iCCA cells (Fig. 7I). The gene discussed is EGFR; the disease is infantile convulsions and choreoathetosis.