Proceeding insights into the disease mechanisms underlying STXBP1-DEE are now paving the way for more targeted therapies that should tackle the whole gamut of comorbidities, including neurodevelopmental, movement disorders, behavioral and psychiatric and gastrointestinal problems, as well as seizures.4 Further studies confirming our findings suggestive of a slowly progressive disease course in at least some of the patients with STXBP1-DEE would provide a rationale to also study the effect of targeted therapy initiation in adolescence/adulthood. The gene discussed is STXBP1; the disease is movement disorder.