AKT1 and cancer: Intracellular free Ca2+, on the one hand, activates multiple oncogenic signaling pathways, including RAC-alpha serine/threonine-protein kinase (AKT) and phosphatidylinositol 3-kinase (PI3K), to upregulate the expression of glucose transporters, such as GLUT1 and GLUT4, thereby promoting the metabolic switch to glycolysis and the survival of cancer cells [184–186].