RHOA and ductal breast carcinoma in situ: We also calculated breast cancer gene signatures for each CNA+ cellular disease state and found many disease state relevant signatures including high expression of interferon signature enriched in prepuberty state; NFKB associated gene signature was enriched in DCIS state; KRAS gene signature was enriched in Tumor1 and RHOA gene signature was enriched in Tumor2 (Fig. 2e; Supplementary File 2).