PGR and cancer: Interestingly we found 5/7 of the Oncotype Dx DCIS non-housekeeping genes constitutively high in the C3Tag cancer cells from all 3 states except Pgr, which was <10% in cells of our murine DCIS states and completely not present in the murine tumor state (Supplementary Fig. 4c); these finding highlights that our CNA high C3Tag cancer cells are expressing genes already used to identify biologically aggressive human DCIS.