Oncotype Dx DCIS score was specifically developed as a prognostic score to identify biologically aggressive human DCIS and consists of 5 proliferative genes (Ki67, STK15, Survivin, CCNB1, and MYBL2), 2 non-proliferation genes (PR, GSTM1) and 5 housekeeping reference genes. This evidence concerns the gene CCNB1 and ductal breast carcinoma in situ.