Copy number aberrant malignant cells were identified and showed increased expression of genes associated with unique biological pathways including Interferon response in prepuberty state, NFKB pathway in DCIS state, and cancer specific pathways like KRAS, p53, Myc, MTORC1 in the IDC state (Fig. 5). This evidence concerns the gene TP53 and ductal breast carcinoma in situ.