Similarly, analysis of macrophages from the 3 states revealed that there were distinct genes in the Tumor macrophages which includes genes like Cotl1, Tgfbi, Fos, and Fn1 along with complement activation genes C1qa, C1qb, and C1qc (Fig. 3e; Supplementary File 3). The gene discussed is COTL1; the disease is neoplasm.