Upon construction of disease state-specific gene signatures, we found that the fibroblasts from the Tumor disease state were distinct (Fig. 3a); these fibroblasts from the Tumor state were associated with increased expression of genes involved in extracellular matrix organization and signaling pathways like Integrin and FGF signaling pathways (Col3a1, Col5a1, Tnc, Sdc2, and Spp1; Supplementary File 3). This evidence concerns the gene SPP1 and neoplasm.