Multiple studies have shown that CCL2 might play crucial roles in monocyte chemotaxis and even the polarization of macrophage.23 24 To determine the correlation between the expression of CCL2 and polarization of TAMs, we examined the CCL2 expression and TAMs biomarkers (Total: CD68, M1-like: CD86, M2-like: CD206) in GC tissues from HER2-positive patients (figure 1F). This evidence concerns the gene ERBB2 and gastric cancer.