ANGPTL8 and cardiac hypertrophy: Serum ANGPTL8 was increased in subjects with hypertension and myocardial hypertrophy (MH) compared with healthy people (2108 ± 134.86 vs 1218 ± 156.74 ng/ml) but was lower than that in subjects with hypertension without complications (2108 ± 134.68 vs 2516 ± 289.21 ng/ml) (Supplementary Table 1 and Fig. 1A).