ANGPTL8 and coronary artery disorder: Higher circulating ANGPTL8 values were associated with all-cause mortality in a 5-year follow-up study, but Leiherer et al. [10] reported that high betatrophin (ANGPTL8, upper tertile, >9.4 ng/ml) was significantly and inversely associated with cardiovascular events or death and improved the risk stratification of the SCORE algorithm in patients with stable coronary artery disease (CAD) during 8 years of follow-up.