To study the molecular mechanisms of this IL-4 induced gain-of-function phenotype, we stably expressed STAT6MUT (D419G, D419N, N421K, or D519V), STAT6WT or EV control in OCI-Ly1 and OCI-Ly8 cells, two B cell lymphoma cell lines that harbor the FL hallmark translocation t(14;18). This evidence concerns the gene IL4 and B-cell non-Hodgkin lymphoma.