Similarly, three of the seven loci: (17q21.32 [ZNF652], 17q21.33 [PHB], and 19q13.32 [TOMM40, APOC2, KLC3, ERCC2]) are putatively novel for GERD given we have no evidence they were previously genome-wide significant for the disorder. This evidence concerns the gene ZNF652 and gastroesophageal reflux disease.