MTSS2 and Alzheimer disease: Of these, the rs33998678 SNP (16q22.1, IL34) is in strong LD (r2 = 0.91) with a genome-wide significant locus found in the AD vs PGM analysis (rs34644948, at 16q22.1, MTSS2, Table 4), providing more support for its involvement in AD and GIT traits (GERD and PUD).