The loci, including 1p31.3 (PDE4B), 3p21.31 (SEMA3F, HYAL2), 6p21.32 (HLA-DRA), and 19q13.32 (TOMM40, APOC2, ERCC2, BCL3, and KLC3), were replicated in AD vs PUD and AD vs PGM meta-analyses and largely reinforced in colocalisation (GWAS-PW) as well as gene-based association analyses. Here, HYAL2 is linked to Alzheimer disease.