An additional 175 independent SNPs at 121 loci reached a genome-wide suggestive association (Pmeta-analysis < 1 × 10−5, Supplementary Data 9), replicating some of the genome-wide significant loci, including: 1p31.3 (PDE4B, lead SNP: rs2840677) and 1q31.1 (BRINP3, rs10753964) for AD and GERD. The gene discussed is PDE4B; the disease is Alzheimer disease.