Of these, the rs33998678 SNP (16q22.1, IL34) is in strong LD (r2 = 0.91) with a genome-wide significant locus found in the AD vs PGM analysis (rs34644948, at 16q22.1, MTSS2, Table 4), providing more support for its involvement in AD and GIT traits (GERD and PUD). This evidence concerns the gene MTSS2 and gastroesophageal reflux disease.