PHB1 and Alzheimer disease: Other identified independent genome-wide significant SNPs and loci mapped to genes including CD46, SEMA3F, HLA-DRA, MTSS2, PHB, and TOMM40. The CD46 gene is a complement regulator which is bactericidal to Helicobacter (H) pylori62 and was also recently identified for AD in a transcriptome analysis63, making it a plausible candidate in both AD and GIT disorders.