Of these, the rs33998678 SNP (16q22.1, IL34) is in strong LD (r2 = 0.91) with a genome-wide significant locus found in the AD vs PGM analysis (rs34644948, at 16q22.1, MTSS2, Table 4), providing more support for its involvement in AD and GIT traits (GERD and PUD). The gene discussed is IL34; the disease is Alzheimer disease.