It is noteworthy that some of the identified AD and GERD shared genes are in chromosomal locations found in our meta-analysis, including 1p31.3 (PDE4B), 3p21.31, (SEMA3F, HYAL2, IP6K1), 6p21.32 (HLA-DRA) and 19q13.32 (Supplementary Data 23). This evidence concerns the gene PDE4B and gastroesophageal reflux disease.