Xp11.2 translocation renal cell carcinoma (Xp11.2 translocation RCC), first classified by WHO in 2004, is characterized by different tanslocations involving chromosome Xp11.2 and consequently results in gene fusions of the transcription factor E3 gene (TFE3) [1]. This evidence concerns the gene TFE3 and hereditary clear cell renal cell carcinoma.