Comparing Dot1L and menin effects on BC cell transcriptome and their chromatin binding sites revealed co-recruitment of both proteins in a significant fraction of genome sites, resulting in co-regulation of genes involved in key BC signaling pathways including, among others, estrogen, p53, HIF1α and death receptor signaling, and the control of cell cycle and epithelial-to-mesenchymal transition. Here, DOT1L is linked to breast cancer.