Since also TAM- or ICI-resistant cells respond in the same way, these results are concordant in suggesting the possibility to target these three factors, either alone or in combinations, with specific inhibitor in new therapeutic regimens against endocrine therapy-resistant breast tumors that still express wt or mutated ERα, to achieve an antiestrogen-like effect due to lower receptor levels that, in turn, cause reduction of cell proliferation and increased cell death. Here, ESR1 is linked to breast neoplasm.