DOT1L and cancer: Functional annotation analysis focusing on the 561 common components of the Dot1L and menin interactomes indicates that these are involved in key molecular processes related to gene transcription and genome structure and activity, such as epigenetic regulation of gene expression, histone binding and chromosome and chromatin organization (Fig. 3G), all taking part in the reprogramming of chromatin landscape that has been recognized as a critical step of the transcriptional response in breast [52] and other cancers.