Taken together, our findings suggested that the adoptive transfer of MDSCs into ApoE−/−Fas−/− mice aggravated atherosclerosis and SLE, whereas depleting MDSCs using anti-Gr-1 antibody ameliorated SLE and atherosclerosis in ApoE−/−Fas−/− mice. The gene discussed is APOE; the disease is systemic lupus erythematosus.