We found that treatment with 17-β-estradiol (E2) impaired the tumorigenic potential of NB cells overexpressing ERα [17] and that GR overexpression led to reduced tumorigenesis both in vitro and in vivo (Figs. 1 and 2, Supplementary Figs. 1-3) [18]. Here, NR3C1 is linked to neuroblastoma.