TP53 and head and neck squamous cell carcinoma: However, in this context, it is interesting to note that in the initial micro array analysis, RanBP17 was found upregulated in CDDP resistant HNSCC cell lines carrying disruptive TP53 mutations but at the protein level, no major difference in expression was seen between CDDP resistant and sensitive HNSCC cell lines as would be expected from the micro array data.