The results showed that the protein expression levels of YAP1, TAZ and CTGF were significantly decreased after OTUB2 knockdown in ESCC cell lines (P < 0.001);but the mRNA expression levels of YAP1, TAZ and CTGF were not significantly decreased after OTUB2 knockdown in ESCC cell lines (Fig. 10). Here, OTUB2 is linked to esophageal squamous cell carcinoma.