After analysis of the relevant clinicopathological parameters, we found that the positive expression of OTUB2 was associated with tumor size (P = 0.003) and degree of differentiation (P = 0.037); The positive expression of YAP1 was mainly associated with tumor size (P = 0.011), degree of differentiation (P = 0.037), pathological stage (P = 0.027), and lymph node metastasis (P = 0.001); The positive expression of TAZ was mainly associated with tumor size (P < 0.001), infiltration depth (P = 0.020), pathological stage (P < 0.001) and lymph node metastasis (P = 0.001) (Table 2). Here, WWTR1 is linked to metastatic malignant neoplasm in the lymph nodes.