CCN2 and esophageal squamous cell carcinoma: The results showed that the protein expression levels of YAP1, TAZ and CTGF were significantly decreased after OTUB2 knockdown in ESCC cell lines (P < 0.001);but the mRNA expression levels of YAP1, TAZ and CTGF were not significantly decreased after OTUB2 knockdown in ESCC cell lines (Fig. 10).