Additionally, we also determined that the expression of YAP1,TAZ and CTGF protein also decreased significantly with the silencing of OTUB2, but the mRNA were not significantly changed, this result is also consistent with the findings in breast cancer by Zhang Z [5] et al.,which suggested that the effect of OTUB2 on YAP1/TAZ may not be regulated by transcriptional level, but by post-transcriptional modification of YAP1/TAZ through its deubiquitinating enzyme action, affecting the protein level of YAP1/TAZ and then exerting synergistic tumor-promoting effects. This evidence concerns the gene WWTR1 and breast cancer.