The expression of OTUB2 was negative in paracancerous tissues (Fig. 2A), but was highly expressed in the cytoplasm of ESCC (Fig. 2B-D); YAP1 and TAZ were negatively expressed in paracancerous tissues (Fig. 3A; Fig. 4A), but was highly expressed in the cytoplasm and was mainly located nucleus of ESCC (Fig. 3B-D; Fig. 4B-D). The gene discussed is WWTR1; the disease is esophageal squamous cell carcinoma.