More than 50 genes related to sarcomeric proteins (MYH7, ACTC1, TNNT2, MYH6, MYBPC3), the cytoskeleton (TTN, DES, DMD, FLNC, NEXN, LDB3), ion channels (RYR2, SCN5A), the nuclear envelope (LMNA, TMPO) and intercellular junctions have been implicated in DCM. The gene discussed is TNNT2; the disease is familial dilated cardiomyopathy.