DES and familial dilated cardiomyopathy: More than 50 genes related to sarcomeric proteins (MYH7, ACTC1, TNNT2, MYH6, MYBPC3), the cytoskeleton (TTN, DES, DMD, FLNC, NEXN, LDB3), ion channels (RYR2, SCN5A), the nuclear envelope (LMNA, TMPO) and intercellular junctions have been implicated in DCM.