IL-7 promoted the cytotoxicity of peripheral CD8+ T cells from melanoma patients (P = 0.0004, Fig. 4a) and controls (P = 0.047, Fig. 4a), as well as tissue-infiltrating CD8+ T cells from tumor tissues (P = 0.023, Fig. 4b) and para-tumor tissues (P = 0.015, Fig. 4b). This evidence concerns the gene CD8A and melanoma.