IL-7 stimulation enhanced total CD127 mRNA level both in peripheral CD8+ T cells from melanoma patients (1.22 ± 0.24 vs. 1.00 ± 0.14; P = 0.0016, Fig. 2d) and controls (1.23 ± 0.21 vs. 1.01 ± 0.11; P = 0.015, Fig. 2d), as well as in tissue-infiltrating CD8+ T cells from tumor tissues (1.17 ± 0.18 vs. 0.93 ± 0.22; P = 0.040, Fig. 2e) and para-tumor tissues (1.29 ± 0.17 vs. 1.07 ± 0.16; P = 0.029, Fig. 2e). This evidence concerns the gene IL7R and melanoma.