CD8A and melanoma: There was no significant difference of total CD127 mRNA either in peripheral CD8+ T cells between melanoma patients and controls (1.03 ± 0.13 vs. 1.03 ± 0.12; P = 0.975, Fig. 1c), or in tissue-infiltrating CD8+ T cells between tumor tissues and para-tumor tissues (0.97 ± 0.19 vs. 1.02 ± 0.14; P = 0.482, Fig. 1c).