Thus, our current data suggested that IL-7-induced sCD127 release by CD8+ T cells might be not related to proteolytic cleavage and shedding of the membrane receptor as described with other cytokine receptors [28, 29], which was not consistent with the in vitro and in vivo regulatory mechanism between mCD100 and sCD100 balance in lung cancer [30] and chronic viral infections [31, 32]. Here, IL7 is linked to lung cancer.