The ORs for mortality were not statistically significant for subgroups including BMI, liver disease, and metastatic solid tumor in eICU-CRD dataset while in the MIMIC-IV dataset, the association between the high HCT-ALB group and mortality was not significant in subgroups including age, gender, BMI, CHF, diabetes, chronic pulmonary disease, renal disease, malignant cancer, and metastatic solid tumor. The gene discussed is ALB; the disease is diabetes mellitus.