TNF and Sepsis: When patients suffered from sepsis, the pathogenic microorganisms in the foci of infection and the various toxins released by them can stimulate the immune system of the body to release a large number of inflammatory mediators such as tumor necrosis factor and interleukins [35], which can impair the function of the vascular endothelial barrier, increase capillary permeability and cause a large amount of plasma extravasation, resulting in a decrease in blood volume and a decrease in the concentration of ALB in plasma [36].