ADARB2 and early-onset autosomal dominant Alzheimer disease: However, multiple recent studies have suggested that ADAR3 is important for both normal learning and memory (16), while aberrant ADAR3 expression occurs in several neuropathological diseases including amyotrophic lateral sclerosis (17), schizophrenia (18), autism spectrum disorder (19) and Alzheimer’s disease (AD) (20, 21, 22).