We observed that, upon lung infections with PP34, MRP8Cre+Casp1flox mice did not show any differences in bacterial elimination or IL1β production, thus confirming previous work that ExoU-expressing Pseudomonas aeruginosa strains promote successful infection independently of the inflammasome pathways (Fig 5B–5D) [49, 50]. The gene discussed is IL1B; the disease is infection.