In addition, similar to Exo1−/−/p53−/− mice, the introduction of a p53 knockout allele led to the rapid deaths of Exo1DA/DA/p53−/− mice between two to three months of age due to the development of T cell lymphoma (100%, n = 17/17) ((5) and not shown). Here, TP53 is linked to T-cell non-Hodgkin lymphoma.