In this capacity, several EV-miRs from CRC cells (miR-25-3p, miR-130b-3p, and miR-425-5p) have been found to induce the tumor-supporting M2 polarization of macrophages (tumor-supporting macrophages) via regulating the PI3K/Akt-PTEN signaling pathway [15]. This evidence concerns the gene PTEN and colorectal carcinoma.