TGFB1 and neoplasm: This dynamic cellular transition is hypothesized to be co-opted by carcinoma to confer an invasive or metastatic phenotype on tumor cells and is reportedly driven by multiple signaling pathways in CRC: (1) The TGF-β signaling, linked to tumor progression, stimulates the expression of EMT markers such as SNAIL, vimentin, and fibronectin.