PTEN and neoplasm: Other examples of metastasis-related EV-miRs include tumor-derived EV-miR-1247-3p, which is known to induce cancer-associated fibroblast activation to foster lung metastasis of liver cancer [16]; EV-miR-25-3p, which promotes extravasation and vascular permeability in the liver and lungs in a mouse model of CRC metastasis, through targeting of the transcription factors Krüppel-like factors 2 and 4 [17]; and EV-miR-214, which upon delivery to mouse peripheral CD4 + T cells downregulates PTEN and promotes Treg expansion [18].