Further IPA canonical pathway analysis of these candidate mRNAs, as shown in Fig. 6A (Top 20) and Table S8, revealed an enrichment of genes with functional implications in several key cellular processes: (1) EMT pathways related to TGF-β, Wnt/β-catenin, and HIF-1α signaling; (2) tumor microenvironment, macrophage, and natural killer cell signaling; (3) inhibition of angiogenesis by TSP1; and (4) PTEN and apoptosis pathways. Here, TGFB1 is linked to neoplasm.