Paradoxically, although chronically elevated low levels of inflammation in the absence of overt infection, also called inflammaging, are characteristic of older adults people [5], peripheral blood mononuclear cells (PBMCs) from older adults demonstrate a decrease in the production of inflammatory and antiviral cytokines upon Toll-like receptor (TLR)7/8 and retinoic acid-inducible gene I (RIG-I) stimulation when compared to their younger counterparts [6]. This evidence concerns the gene RIGI and infection.