SLC39A12 and pulmonary arterial hypertension: Their expression and functional roles in vascular physiology and diseases had been paid little attention (Zalewski et al. 2019) until the recent ground-breaking finding that ZIP12 is at least partly responsible for hypoxia-induced PAH in both human and rats (Zhao et al. 2015), inspiring other studies into this field (Tran et al. 2021; Xiao et al. 2021; Zhu et al. 2022).