Nonetheless, in specific areas showing hypometabolism in AD [26], such as lateral parietal and middle frontal lobe, this positive association between plasma GFAP and [18F]FDG uptake occurred in the group of individuals who were still tau-negative (T-) but the correlation turned negative in the group of tau-positive (T +) individuals. The gene discussed is GFAP; the disease is Alzheimer disease.