Thus, in this work, we studied the associations between plasma and CSF GFAP, markers of astroglial reactivity, with [18F]FDG uptake in the brain of cognitively unimpaired individuals, many of them early in the Alzheimer’s continuum. As it has been hypothesized that the evolution of glial biomarkers is not monotonic in the course of AD [42, 43], we also investigated interactions as a function of AT stages [44]. This evidence concerns the gene GFAP and Alzheimer disease.