WASF2 and neoplasm: EMX1 suppressed the transcription of WASF2 to inactivate the Wnt/β‐catenin pathway. The tumor‐suppressive effects of EMX1 were blocked upon WASF2 restoration, and the SCG cell growth and metastasis triggered by WASF2 was suppressed by artificial Wnt/β‐catenin inhibition. Taken together, we opine that EMX1 suppresses WASF2 transcription and inactivates the Wnt/β‐catenin axis pathway to suppress SCG development.