Of note, in the present study, restoration of WASF2 in SCG cells blocked the role of EMX1 and rescued the cell growth and invasiveness in vitro, as well as the tumor growth and metastasis in vivo, indicating that the WASF2 downregulation is possibly implicated in the tumor‐suppressing role of EMX1 in SCG. Here, WASF2 is linked to neoplasm.