Downregulation of EMX1/EMX2 genes has been documented to be correlated with the development of several epithelial‐originated solid tumors, such as gastric cancer (Li et al., 2012), lung cancer (Kim et al., 2011; Okamoto et al., 2011), endometrial cancer (Daftary & Taylor, 2004), and colorectal cancer (Aykut et al., 2017), and restoration of these genes suppressed cancer progression. The gene discussed is EMX2; the disease is colorectal cancer.