Nrf2 inhibits ferroptosis mainly by activating iron metabolism-related genes (SLC40A1 and MT1G), GSH metabolism-related genes (SLC7A11 and GCLM), and ROS detoxification enzymes (AKR1C1 and NQO1) in many cancers (Chen et al., 2021b). Here, SLC7A11 is linked to cancer.