Studies have shown that caspase-1 can cleave several key enzymes in glycolysis, including aldolase, triose-phosphate isomerase, glyceraldehyde-3-phosphate dehydrogenase, alpha-enolase, and pyruvate kinase, which are further involved in the occurrence of sepsis and septic shock (Shao et al., 2007). The gene discussed is CASP1; the disease is Sepsis.