AKT1 and liver cancer: In addition to sorafenib, various chemotherapeutic drugs commonly used for treating liver cancer, including gefitinib, paclitaxel, 5-fluorouracil, etoposide, doxorubicin, vinblastine, docetaxel, gemcitabine, cytarabine, AKT inhibitor VIII, sunitinib and metrhotrexate, by blocking the cell cycle, promoting cell death, suppressing specific signaling pathways and inhibiting angiopoiesis.