Glycolytic enzyme enolase 1 (ENO1), acting as an RNA-binding protein, facilitates the mRNA degradation of IRP1 to mediate iron homeostasis, inhibits the expression of mitoferrin-1 (Mfrn1) and suppresses ferroptosis in HCC cells, suggesting that the ENO1-IRP1-Mfrn1 axis regulates the pathogenesis of HCC and ferroptotic cell death (Zhang et al., 2022). This evidence concerns the gene ACO1 and hepatocellular carcinoma.