As shown in Figures 1A,B, the expression of HSPA5, EMC2, SLC7A11, HSPB1, GPX4, FANCD2, CISD1, FDFT1, SLC1A5, TFRC, RPL8, DPP4, CS, CARS1, ATP5MC3, ALOX15, ACSL4 and ATL1 was significantly increased in HCC tissues compared with normal liver tissues. This evidence concerns the gene GPX4 and hepatocellular carcinoma.