Copper metabolism MURR1 domain 10 (COMMD10) suppressed HIF1α degradation and the nuclear translocation of HIF1α, thus inhibiting the transcription of ceruloplasmin and SLC7A11 to increase ferroptosis and radiosensitivity by disrupting Cu-Fe homeostasis in HCC (Yang et al., 2022). This evidence concerns the gene HIF1A and hepatocellular carcinoma.