Consistent with the results obtained from TCGA (Figure 1), upregulated expression of SLC7A11, SLC1A5, TFRC, RPL8 and CARS1 was observed in HCC tissues compared with adjacent normal liver tissues according to the TCGA + GTEx and ICGC databases (Figures 5C,D). This evidence concerns the gene RPL8 and hepatocellular carcinoma.