As shown in Figures 1A,B, the expression of HSPA5, EMC2, SLC7A11, HSPB1, GPX4, FANCD2, CISD1, FDFT1, SLC1A5, TFRC, RPL8, DPP4, CS, CARS1, ATP5MC3, ALOX15, ACSL4 and ATL1 was significantly increased in HCC tissues compared with normal liver tissues. The gene discussed is ATP5MC3; the disease is hepatocellular carcinoma.