JAK1 and breast neoplasm: Based on those phosphorylation patterns, a computational upstream kinase analysis predicted increased activity of PTKs that are known to contribute to invasive progression and metastasis of breast tumor, namely, FLT4, JAK1b, TRKB, and FLT1 (Zhang et al., 2010; Qian et al., 2015; Choy et al., 2017; Wehde et al., 2018).