Although the expression of MIC-A/B or other ligands of NKT cells and γδ T cells receptors has not been reported on the surface of cystic cells in ADPKD, the fact that the MICA gene contains an NF-κB-binding site which is necessary and sufficient for transcriptional transactivation of MICA in response to TNFα in primary endothelial cells (ECs) (Lin et al., 2012), suggests a potential of MICA being expressed on cystic renal epithelial cells in ADPKD kidneys. The gene discussed is NFKB1; the disease is autosomal dominant polycystic kidney disease.