In addition, this study found that hypermethylation of the PKD1 gene body (exon 43) in ADPKD patient samples, negatively correlated with the PKD1 gene expression, suggesting that epigenetic silencing of the PKD1 gene is involved in kidney cyst development (Woo et al., 2014) (Table 1). This evidence concerns the gene PKD1 and autosomal dominant polycystic kidney disease.