In Pkd1 mutant model, the deacetylase sirtuin 1 (SIRT1) is upregulated and treatment with pan-sirtuin inhibitor (nicotinamide) or a SIRT1-specific inhibitor (EX-527) delayed cyst growth through the deacetylation of p53, which released its inhibition on apoptosis in Pkd1 mutant mice (Zhou et al., 2013). This evidence concerns the gene TP53 and cyst.