However, oral supplement with trehalose, a natural autophagy enhancer, showed no effect on the progression of ADPKD in Pkd1 miRNA transgenic mice and could not restore impaired autophagy, suggesting that an oral supplement of trehalose may not affect the progression of ADPKD (Chou et al., 2018). The gene discussed is PKD1; the disease is autosomal dominant polycystic kidney disease.