Lipid peroxidation correlated with cyst growth and the activation of TMEM16A (anoctamin 1), a chloride bicarbonate transmembrane channel, inducing growth of renal cysts by lipid peroxidation while the direct inhibition of TMEM16A or inhibition of lipid peroxidation delayed cyst development in Pkd1 mutant mice (Schreiber et al., 2019). The gene discussed is ANO1; the disease is cystic kidney disease.