SOD1 and autosomal dominant polycystic kidney disease: The expression of antioxidant enzymes GPX and SOD and their activity were decreased in cpk mice and Han:SPRD rats (Maser et al., 2002) while lipid peroxidation is increased in human ADPKD patients (Schreiber et al., 2019), suggesting that ferroptosis plays an important role in ADPKD.