IGKV1D-22 and autosomal dominant polycystic kidney disease: The serum levels of HMGB1 are increased in ADPKD patients (Nakamura et al., 2011; Nakamura et al., 2012), while S100A8 and A9 were found to be remarkably increased in both ADPKD patients and mouse models (Lee et al., 2015).