In Pkd1fl/fl:Smyd2+/+:Ksp-Cre neonates, apoptosis was rare in kidneys and knockout of Smyd2 induced cyst-lining epithelial cell death in kidneys from Pkd1fl/fl:Smyd2fl/fl:Ksp-Cre neonates (Li et al., 2017b). The gene discussed is SMYD2; the disease is cyst.