IFNG and autosomal dominant polycystic kidney disease: The exact roles of NKT cells in ADPKD are not clear, however, it has been reported that kidney injury induces the activation of NKT cells, and causes hematuria and nephritic casts by damaging glomerular endothelial cells in a perforin-dependent manner through secretion of IFN-γ and other mechanisms and result in kidney dysfunction (Turner et al., 2018).