Simultaneously, transfection with a miR-192 or miR-215 mimic reversed this increase in HepG2 and SK-HEP-1 cells (Figures 6A–D), which indicates that circKIF5B sponges miR-192 and miR-215 to regulate XIAP expression in HCC cells. The gene discussed is XIAP; the disease is hepatocellular carcinoma.