NFATC4 and breast cancer: Therefore, we focused our attention on the N- and C-terminal sequences of NFAT1 and NFAT3 that had isotype specificity (Figure 1A) and identified a specific region of 85 amino acids, in the C-terminal part of NFAT3, required for the inhibition of cell invasion of the human luminal breast cancer cell line T-47D.