In this context, we have previously uncovered the anti-invasive role of NFAT3 in luminal breast cancer (4) and shown that extracellular vesicles (EVs) produced by NFAT3-expressing luminal breast cancer cells were competent to prevent tumor growth and restrain metastases spreading in a murine triple- negative breast cancer model (7). This evidence concerns the gene NFATC4 and neoplasm.