FBXO9 is a mysterious member of the F-box protein family (16), and a few available studies have shown that FBXO9 is involved in the development of the nervous system or adipose tissue (17, 18), in pathological changes in the muscle in diabetes (17) and epithelial damage in respiratory distress syndrome (18), and in the adverse effects of zoledronic acid (19) or as a target of sepsis (18), and participates in disease progression in hematological tumors by regulating the activity of the mTOR pathway (20) and the proteasome (8). Here, FBXO9 is linked to diabetes mellitus.