As xenotransplants of KYSE150 cells secreting exosomes containing miRNA-320b showed a greater number of metastatic lymph nodes, it was concluded that in ESCC, METTL3 increases miRNA-320b, which suppresses PDCD4 and activates the AKT pathway, increasing tumorigenic effects. Here, PDCD4 is linked to esophageal squamous cell carcinoma.