MEG3 expression was shown to be lower in SW480, HT29 and HCT-116 CRC cell lines compared to normal NCM460 colon epithelial cells and suppressed further in oxaliplatin resistant HT29/OXA and HCT-116/OXA cell lines, indicating a relationship with chemo-resistance as well as tumorigenesis. The gene discussed is MEG3; the disease is colorectal carcinoma.