In ESCC cell lines, miRNA-141 silencing decreases cell proliferation, migration and invasion (180), whereas increased expression downregulates SOX17, thereby activating the Wnt signalling pathway (181), and/or pleckstrin homology domain leucine-rich repeat protein phosphatase-2 (PHLPP2) which subsequently increases the activity of Akt/PI3-K pathway (182). This evidence concerns the gene AKT1 and esophageal squamous cell carcinoma.