As xenotransplants of KYSE150 cells secreting exosomes containing miRNA-320b showed a greater number of metastatic lymph nodes, it was concluded that in ESCC, METTL3 increases miRNA-320b, which suppresses PDCD4 and activates the AKT pathway, increasing tumorigenic effects. The gene discussed is AKT1; the disease is esophageal squamous cell carcinoma.