VEGFA and metastatic colorectal cancer: Bevacizumab (Bev) is a humanized vascular endothelial growth factor monoclonal antibody that is used with chemotherapeutic drugs, including 5-fluorouracil (5-Fu) or capecitabine, oxaliplatin or/and irinotecan-based chemotherapy, for the treatment of metastatic colorectal cancer (mCRC) (1–3).