The use of immunosuppressants of PD-1 and CTLA-4 to treat malignant tumors has also been successful in a variety of tumors, but the efficacy in gliomas has been unsatisfactory. Therefore, the TIDE score was selected to assess the efficacy of PD1 and CTLA4 immunotherapy in the two risk groups. Our results show that the high-risk patients may respond well to immune checkpoint therapy (PD-1, CTLA4) and benefit from immunotherapy. The gene discussed is CTLA4; the disease is central nervous system cancer.