TRPM8 and Familial prostate cancer: TRPM8 adversely affected three tumor types, namely, breast (Figure 5A, RFS: Cox P = 0.022), esophageal (Figure 5C, OS: Cox P = 0.001), and lung (Figures 5D, E, OS: Cox P = 0.003; RFS: Cox P < 0.001) cancers but appeared to have a protective function in colorectal (Figure 5B, OS: Cox P <0.001) and prostate cancers (Figure 5F, OS: Cox P = 0.006).