According to the results, there exist different causal variants and functional mechanisms in relationships of variants in the TERT-CLPTM1L regions with idiopathic pulmonary fibrosis, myeloproliferative neoplasms, and glioma, as well as esophageal, gastric, bladder, lung, pancreatic, and skin cancer predisposition. The gene discussed is TERT; the disease is glioma.