Furthermore, current evidence demonstrates that rs31489, a variant in which C is changed to A in CLPTM1L gene, could influence the telomere length that could decrease the risk of nonsmokers’ lung carcinoma (rather than in smokers), because smoking can counteract the protective role of A allele, shorten telomere length, and enhance telomerase activity (46). Here, CLPTM1L is linked to lung carcinoma.