Moreover, our study offers foundation for further demonstrating that the variants in the TERT-CLPTM1L genes are related to the risk of idiopathic pulmonary fibrosis, myeloproliferative neoplasms, glioma, esophageal cancer, gastric cancer, bladder cancer, lung cancer, pancreatic cancer, and skin cancer. The gene discussed is TERT; the disease is esophageal cancer.