Apart from that, SNP rs2736100 and SNP rs2853691 are intron variants of the TERT gene, and they are linked with predisposition of esophageal cancer in our study; while in our study, it was found that rs2736100 is unrelated to rs2853691 in Europeans, East Asians, and Africans (r2 < 0.05 for all tests), revealing that there might exist various functional mechanisms for relationships of TERT variants with predisposition of esophageal cancer. The gene discussed is TERT; the disease is esophageal cancer.