Briefly, our research offers comprehensive epidemiological evidence that common variants in the TERT-CLPTM1L region show association with predisposition of glioma, myeloproliferative neoplasms, idiopathic pulmonary fibrosis, esophageal cancer, gastric cancer, skin cancer, bladder cancer, lung cancer, and pancreatic cancer. The gene discussed is TERT; the disease is central nervous system cancer.