Similar positive correlations between the expression of AQP3 and MMP-2 or MMP-3 have been reported in lung cancer and prostate cancer cells (105, 106), and in this case, upregulation of MMP-3 seems to be related to ERK1/2 pathways, as has been reported for AQP5 (10). This evidence concerns the gene MMP3 and prostate carcinoma.