Finally, a large-scale expression study based on using different types of tumor samples (90) demonstrated significant AQP3 protein expression in resected samples from pituitary adenomas, salivary gland tumors, thymic tumors, germinal cell tumors of the ovary and testis, urothelial carcinoma of the bladder, adenocarcinoma of the lung and prostate, squamous cell carcinomas of the skin, esophageal cancer, cancer of the uterine cervix, and apocrine carcinoma of the breast. The gene discussed is AQP3; the disease is neoplasm.