CDH1 and colorectal carcinoma: E-cadherin downregulation is associated with certain malignant characteristics, including tumor progression, the loss of differentiation, invasion, and metastasis (18), The study demonstrated that E-cadherin was a metastasis prediction marker and a pre-therapeutic prognostic marker for patients with CRC and hepatic metastases (19).In addition, T-cell migration is related to immunity and is involved in the tumor immune microenvironment to regulate tumor progression and is currently an attractive therapeutic target (20).