E-cadherin downregulation is associated with certain malignant characteristics, including tumor progression, the loss of differentiation, invasion, and metastasis (18), The study demonstrated that E-cadherin was a metastasis prediction marker and a pre-therapeutic prognostic marker for patients with CRC and hepatic metastases (19).In addition, T-cell migration is related to immunity and is involved in the tumor immune microenvironment to regulate tumor progression and is currently an attractive therapeutic target (20). The gene discussed is CDH1; the disease is neoplasm.