The low intracellular content of ROS is related to the enhanced expression of the homing receptors CCR2, CXCR3 and CCR7, which promote both entry and accumulation of CLL cells in the pro-survival tumor microenvironment of lymphoid organs, eventually enhancing leukemic cell survival (4, 5, 7, 8). This evidence concerns the gene CCR2 and B-cell chronic lymphocytic leukemia.