The low intracellular content of ROS is related to the enhanced expression of the homing receptors CCR2, CXCR3 and CCR7, which promote both entry and accumulation of CLL cells in the pro-survival tumor microenvironment of lymphoid organs, eventually enhancing leukemic cell survival (4, 5, 7, 8). The gene discussed is CXCR3; the disease is B-cell chronic lymphocytic leukemia.