CCR2 and B-cell chronic lymphocytic leukemia: Since the transcriptional activity of the p65 subunit of NF-κB is affected in CLL cells (24), we performed Chromatin Immunoprecipitation (ChIP) assays on MEC-1 cells to assess whether p65 binds to the ccr2, cxcr3 and ccr7 promoters (Table 1).