Here we added a tile to the puzzle by demonstrating that the low intracellular content of ROS contributes to promote the activation of the p65 subunit of NF-κB in CLL cells, which in turn transcriptionally enhances the expression of the homing receptors CCR2, CXCR3 and CCR7. Here, NFKB1 is linked to B-cell chronic lymphocytic leukemia.