NFKB1 and B-cell chronic lymphocytic leukemia: Conversely, reconstitution of CLL cells with wild-type p66Shc, but not with the p66QQ mutant, elicited an impairment in both NF-κB-dependent luciferase activity and NF-κB phosphorylation under basal conditions comparable to H2O2 treatment in control cells (Figures 5D–F).