Cytoscape showed that the metabolites and gene functions were co-enriched for “arachidonic acid metabolism”, suggesting that colonic lipid metabolites potentially inhibit inflammatory-cancer development by suppressing Ptger2, Pla2g4f and Ptges expression, PGE2/EP2 ligand/receptor binding and activation of intracellular related signaling (Figure 6B). Here, PTGES is linked to cancer.