The GR functioned as a tightly regulated homeostatic machinery of tumor microenvironment homeostasis disruption, reflecting on the stress signaling factors and pathways triggered by solid tumor necrosis and tissue remodeling, which was indicative of the fact that any modifications in the alteration of GR activity would cripple the feedback regulation and contribute to pathogenesis (45). This evidence concerns the gene NR3C1 and neoplasm.