Despite the fact that, similar to a previous study, we have found that ONECUT2 gene expression was increased in the neoplastic tissues in comparison with paired samples obtained from non-neoplastic mucosa, we have found that reduced levels of ONECUT2, rather than its induction, are a poor prognosis predictor in patients with GC and peritoneal disease (39). This evidence concerns the gene ONECUT2 and disease of peritoneum.