Because the abovementioned data demonstrated that LIFR expression increases in patients with peritoneal involvement, we have then investigated whether the LIF/LIFR signaling drives the EMT transition using GC cell lines (Figure 5A) and found that the poorly differentiated cell line MKN45 shows the strongest expression of LIFR in comparison with KATO III and the more differentiated cell line, MKN74. This evidence concerns the gene LIF and gastric cancer.