In addition, preclinical in vivo studies using genetically modified C57BL6/KaLwRij mice with RUNX family transcription factor 2 (RUNX2) deficient osteoblasts indicate that RUNX2 deficiency in MM osteoblasts, triggers myeloma cells and enhances myeloma dissemination and growth (84). This evidence concerns the gene RUNX2 and Miyoshi myopathy.