NFKB1 and hepatocellular carcinoma: Additionally, the signaling pathways implicated in immune and inflammatory responses included “neutrophil degranulation,” “cytokine to cytokine receptor interaction,” “FceRI-mediated NF-κB activation,” “FceRI-mediated MAPK activation,” “FCGR activation,” and “CD22-mediated BCR regulation.” Inflammatory cytokines can drive the progression of HCC.