CD274 and neoplasm: Emergent molecular prognostic factors, including epidermal growth factor receptor (EGFR), microsatellite instability (MSI), tumor mutation burden (TMB) and programmed death-ligand 1 (PD-L1) expression (22, 23), and detailed information on competing risks, such as comorbidities, which may influence overall survival especially in older adults (24), are not included in the SEER database, and therefore could not be explored.