First domain proteins ASAP3 (ankyrin repeat and PH domain-containing protein 3), ARAP1 (Arf-GAP with Rho-GAP domain), MAML1, ADAM8, Notch1 were found to be significantly down expressed in CML cases, while HIF1α, IKZF1 (Ikaros), BIRC2 (inhibitor of apoptosis protein 2/Survivin) were upregulated in case. This evidence concerns the gene HIF1A and chronic myelogenous leukemia, BCR-ABL1 positive.