The second domain shows that MMP27, CFLAR (FADD-like apoptosis factor), S110 (interferon-induced protein), MMP25, IFI16 (gamma interferon-inducible protein 16), IRAK2 (interleukin 1 receptor-associated kinase-like 2), and 18RA (interleukin 18 receptor accessory protein) were significantly downregulated in blast crisis cells of CML patients. Here, IRAK2 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.