The third domain indicates that CAR14 (Caspase recruitment domain-containing protein 14), APAF (apoptotic protease activating factor 1), WWP (NEED4-like E3 ubiquitin-protein ligase), M3K14 (Mitogen activating protein kinase 1), CARD9 (Caspase recruitment domain-containing protein 9), TRI22 (E3 ubiquitin-protein ligase), PPIL2 (Ring type E3 ubiquitin-protein ligase), CAR11 (Caspase recruitment domain-containing protein 11), M3K15 (Mitogen-activated protein kinase 15), DEDD2 (DNA binding death effector domain-containing protein 3) were found to be significantly downregulated in CML patients. This evidence concerns the gene UBE2E3 and chronic myelogenous leukemia, BCR-ABL1 positive.