The LC/MS and RT-PCR results confirmed that all the factors associated with the ubiquitin proteasomal pathway (WWP, M3K14, TRI22, PPIL2, M3K15, etc.)and apoptosis factors (CAR14, APAF, CARD1, CAR11, DEDD2, CFLAR, etc.)expression is decreased in CML patients compared with healthy controls, while the anti-apoptotic protein survivin protein (BIRC2) expression increases in blast crisis cells, so the overall findings reveal that there is no anoikis in CML cells. Here, DEDD2 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.