On the other hand, genes that are found to be tumor suppressive in the blast crisis cells of CML patients are Notch1 (fold change: -0.95244), CDH1 (fold change: -1.2873), Lgd (fold change: -3.3169), CD11d (fold change: -0.82285), UBQLN2 (fold change: -0.97842), RPS18/18a (fold change: -1.3097/-1.4092), PGGT1B (fold change: -0.89755), and GAPDH (fold change: -0.84476), which are significantly (p <0.0001) downregulated, and their fold change is mentioned in Table 4 (see also Table S6) and Figures 4A–Y. This evidence concerns the gene ITGAD and chronic myelogenous leukemia, BCR-ABL1 positive.