About 1-week after the induction when pigmented melanoma lesions became visible, animals (n=4-8/group) were treated via intraperitoneal injection of the solvent control, the MEK inhibitor trametinib (TRA, 3 mg/Kg) either alone or together with chloroquine (CQ, 40 mg/kg) (Figure 1A). Here, MAP2K7 is linked to melanoma.