ESR1 and benign prostatic hyperplasia: Enzymes are involved directly in these diseases or increasing the progression of the disease such as 5α-reductase, estrogen-related receptor gamma (ERR-γ), and estrogen receptors α and β. Estrogen has an important role in the progression, growth, and proliferation of prostate cells and, with combination of DTH, can have an extra effect on BPH [20].